期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 34, 期 -, 页码 1261-1266出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0341261
关键词
blood-brain barrier; dystroglycan; extracellular matrix; focal ischaemia; integrin; matrix adhesion receptor
资金
- NINDS NIH HHS [R37 NS038710, R01 NS053716, R01 NS026945, R01 NS038710] Funding Source: Medline
The integrity of the cerebral microvasculature depends on the interaction between its component cells and the extracellular matrix, as well as reorganized cell-cell interactions. In the central nervous system, matrix adhesion receptors are expressed in the microvasculature and by neurons and their supporting glial cells. Cells within cerebral microvessels express both the integrin and dystroglycan families of matrix adhesion receptors. However, the functional significance of these receptors is only now being explored. Endothelial cells and astrocytes within cerebral capillaries co-operate to generate and maintain the basal lamina and the unique barrier functions of the endothelium. Integrins and the dystroglycan complex are found on the matrix-piroximate faces of both endothelial cells and astrocyte end-feet. Pericytes rest against the basal lamina. in the extravascular compartment, select integrins are expressed on neurons, microglial cells and oligodendroglia. Significant alterations in both cellular adhesion receptors and their matrix ligands occur during focal cerebral ischaemia, which support their functional significance in the normal state. We propose that matrix adhesion receptors are essential for the maintenance of the integrity of the blood-brain permeability barrier and that modulation of these receptors contributes to alterations in the barrier during brain injury.
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