期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 496, 期 2, 页码 780-791出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2015.10.072
关键词
Powder fluidization; Dry powder inhaler; Breath-actuated; Optical diagnostics; High-speed imaging; Particle image velocimetry; Powder emission
Effective drug delivery to the lungs by a DPI device requires the air-stream through the device to have sufficient power to aerosolise the powder. Furthermore, sufficient turbulence must be induced, along with particle-wall and particle-particle collisions, in order to de-aggregate small drug particles from large carrier particles. As a result, the emitted and the fine particle doses produced by many commercially available DPI devices tend to be strongly affected by the natural inter-patient variability of the inhaled air flow. The Nexthaler (R) is a multi-dose breath-actuated dry-powder inhaler with minimum drug delivery-flow rate dependency and incorporating a dose protector. The actuation mechanism of the dose-protector ensures that the dose is only exposed to the inhaled air flow if the flow has sufficient power to cause complete aerosolisation. For this study, a proprietary lactose placebo powder blend was filled into transparent Nexthaler (R) to allow application of high-speed imaging and particle image velocimetry (PIV) techniques to successfully interrogate and reveal details of the powder entrainment and emission processes coupled with characterisation of the flow environment in the vicinity of the mouthpiece exit. The study showed that fluidisation of the bulk of the powder occurs very quickly (similar to 20 ms) after withdrawal of the dose protector followed by powder emission from the device within similar to 50 ms thereafter. The bulk of the metered placebo dose was emitted within 100-200 ms. The visualisation study also revealed that a very small fraction of powder fines is emitted whilst the dose protector still covers the dosing cup as the flow rate through the device accelerates. The PIV results show that the flow exiting the device is highly turbulent with a rotating flow structure, which forces the particles to follow internal paths having a high probability of wall impacts, suggesting that the flow environment inside the Nexthaler1 DPI will be very beneficial for carrier-drug de-aggregation. (C) 2015 Elsevier B.V. All rights reserved.
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