期刊
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
卷 21, 期 6, 页码 719-726出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14756360600810399
关键词
medicinal plants; cleome arabica; aristolochia longa; phenolic compounds; carboxylesterase; inhibition; antioxidant activity
Carboxylesterases (CE), expressed at high levels in human liver and intestine, are thought to detoxify xenobiotics. The goal of this study was to study the effect of phenolic compounds from several plants from the Algerian Atlas used traditionally in Arab folk medicine on the enzymatic activity of porcine liver carboxylesterase. The plants have shown a potent inhibition of carboxylesterase (CE) enzymatic activity in a concentration- dependent manner. Results indicate that the Phenolic extracts from these plants lead to the inactivation of the CE pI 5.1 with K-i values in micromolar range (1.4-38 mu M). These results encourage further biological investigation and identification the inhibitors responsible for this activity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据