期刊
DEVELOPMENT
卷 133, 期 23, 页码 4613-4617出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.02678
关键词
zebrafish; time-lapse microscopy; neurulation; cyclopia; quantitative analyses
资金
- Medical Research Council [G0400709] Funding Source: Medline
- Medical Research Council [G0400709] Funding Source: researchfish
- MRC [G0400709] Funding Source: UKRI
Mechanisms for shaping and folding sheets of cells during development are poorly understood. An example is the complex reorganisation of the forebrain neural plate during neurulation, which must fold a sheet into a tube while evaginating two eyes from a single contiguous domain within the neural plate. We, for the first time, track these cell rearrangements to show that forebrain morphogenesis differs significantly from prior hypotheses. We postulate a new model for forebrain neurulation and demonstrate how mutations affecting two signalling pathways can generate cyclopic phenotypes by disrupting normal cell movements or introducing new erroneous behaviours.
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