期刊
NEUROSCIENCE
卷 143, 期 2, 页码 351-375出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2006.09.019
关键词
ionotropic receptor; metabotropic receptor; presynaptic; extrasynaptic; immunogold; electron microscope
资金
- NCRR NIH HHS [P51 RR000165, RR00615] Funding Source: Medline
- NINDS NIH HHS [R01 NS037423, R01 NS037948, R01 NS42937, R01 NS042937] Funding Source: Medline
GABA and glutamate, the main transmitters in the basal ganglia, exert their effects through ionotropic and metabotropic receptors. The dynamic activation of these receptors in response to released neurotransmitter depends, among other factors, on their precise localization in relation to corresponding synapses. The use of high resolution quantitative electron microscope immunocytochemical techniques has provided in-depth description of the subcellular and subsynaptic localization of these receptors in the CNS. In this article, we review recent findings on the ultrastructural localization of GABA and glutamate receptors and transporters in monkey and rat basal ganglia, at synaptic, extrasynaptic and presynaptic sites. The anatomical evidence supports numerous potential locations for receptor-neurotransmitter interactions, and raises important questions regarding mechanisms of activation and function of synaptic versus extrasynaptic receptors in the basal ganglia. (c) 2006 IBRO. Published by Elsevier Ltd. All rights reserved.
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