期刊
JOURNAL OF MAGNETIC RESONANCE IMAGING
卷 24, 期 6, 页码 1386-1392出版社
JOHN WILEY & SONS INC
DOI: 10.1002/jmri.20765
关键词
hemodynamics; shear stress; MRI; endothelial; frequency; atherosclerosis
资金
- NHLBI NIH HHS [5T32HL0084] Funding Source: Medline
Purpose: To determine the heterogeneity of the time-varying shear stress profiles in the human carotid bifurcation, a region prone to atherosclerosis. Materials and Methods: Lagrangian bicubic interpolation of phase-contrast MRI images was used to determine the shear stress profiles for three adult healthy male volunteers. Frequency spectra for the common and internal carotid artery (CCA and ICA, respectively)-derived shear stresses were examined in order to determine the presence of significant heterogeneity in the intensity distribution. Results: Hemodynamic characteristics (peak, minimum, average shear stress. and oscillatory shear index [OSI]) were highly heterogeneous both along the length of the vessel as well as circumferentially around the CCA and ICA. In the frequency domain, intensities below 4 Hz were significantly higher in the CCA compared to the sinus region of the ICA, indicating that shear stress heterogeneity can be detected in the frequency domain. The harmonic index, a measure of the relative contributions of dynamic and static components of the shear stress signal, colocalizes with OSI, which implies a relationship between specific frequency components and atherosclerosis development. Conclusion: These findings indicate that the time and frequency dependent parameters of in vivo shear stress have important implications for regional development of atherosclerosis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据