期刊
EXPERT OPINION ON THERAPEUTIC TARGETS
卷 10, 期 6, 页码 851-866出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/14728222.10.6.851
关键词
c-reactive protein; ezetimibe; high-density lipoprotein cholesterol; sitosterolaemia; statin; triglyceride
Ezetimibe, an intestinal cholesterol absorption inhibitor, lowers circulating low-density lipoprotein cholesterol (LDL-C) levels both when administered as monotherapy and in combination with other hypolipidaemic drugs, mostly statins. This review focuses on the effects of ezetimibe on non-LDL-C-associated variables. in most studies, ezetimibe effectively reduced triglyceride and increased high density lipoprotein cholesterol levels. The authors also consider the effect of ezetimibe on other variables such as C-reactive protein levels, insulin sensitivity and endothelial function. Ezetimibe is useful in patients with sito-sterolaemia (a rare inherited disorder) as it significantly reduces plasma phytosterol concentrations. Ezetimibe fulfils two of the three essential characteristics of any drug (efficacy and safety). However, clinical studies are required to provide evidence of its ability to reduce vascular events.
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