期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 492, 期 1-2, 页码 266-274出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2015.06.014
关键词
Phosphorus dendrimer; Photosensitizer; Rose bengal; Methylene blue; Photodynamic therapy; Drug delivery system
资金
- project Phosphorus dendrimers as carriers of photosensitizers in photodynamic therapy and its combination with hyperthermia in in vitro studies operated within the Foundation for Polish Science VENTURES Programme (Project VENTURES) [VENTURES/2013-11/3]
- EU European Regional Development Fund
- grant HARMONIA Studying phosphorus dendrimers as systems transporting photosensitizers, National Science Centre [UMO-2013/08/M/NZ1/00761]
Dendrimers due to their unique architecture may play an important role in drug delivery systems including chemotherapy, gene therapy and recently, photodynamic therapy as well. We investigated two dendrimer-photosensitizer systems in context of potential use of these systems in photodynamic therapy. The mixtures of an anionic phosphorus dendrimer of the second generation and methylene blue were studied by UV-vis spectroscopy while that of a cationic phosphorus dendrimer (third generation) and rose bengal were investigated by spectrofluorimetric methods. Spectroscopic analysis of these two systems revealed the formation of dendrimer-photosensitizer complexes via electrostatic interactions as well as p stacking. The stoichiometry of the rose bengal-cationic dendrimer complex was estimated to be 7:1 and 9:1 for the methylene blue-anionic dendrimer complex. The results suggest that these polyanionic or polycationic phosphorus dendrimers can be promising candidates as carriers in photodynamic therapy. (C) 2015 Elsevier B.V. All rights reserved.
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