期刊
JOURNAL OF CONTROLLED RELEASE
卷 116, 期 3, 页码 360-364出版社
ELSEVIER
DOI: 10.1016/j.jconrel.2006.09.003
关键词
trace elements; cooperative encapsulation; controlled-release; core-shell structure; bioactivity
The multiple biologically active trace element delivery remains a problem in regeneration medicine and tissue engineering. A novel approach to fabricate the biologically active trace elements assembly in a core-shell system for cooperative controlled-release has been proposed. Firstly, using a pH-dependent electrostatic interaction, zinc and strontium ions were incorporated into the silica gel nanospheres. Subsequently a porous octacalcium phosphate (OCP) shell was coated on the nanospheres tailored by poly(acrylate sodium) molecules. In vitro test shows that this hierarchical multilayered nanostructure can achieve a shell-/pH-dependent controlled-release of silicon, strontium and zinc ions. The wet-chemical route to selective synthesis of the core-shell Silica@OCP system may provide a general model to develop cooperative encapsulation of biologically active ions in a silica-based system by using layer-by-layer assembly technique for controlled-release in biomedical areas. (c) 2006 Elsevier B.V. All rights reserved.
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