期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
卷 1758, 期 12, 页码 1902-1921出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamem.2006.09.011
关键词
sphingolipid; ceramide; sphingosine; sphingosine-1-phosphate; ceramide-1-phosphate; membrane domain; membrane order; membrane permeability; membrane fusion; flip-flop
Some of the simplest sphingolipids, namely sphingosine, ceramide, some closely related molecules (eicosasphingosine, phytosphingosine), and their phosphorylated compounds (sphingosine-1-phosphate, ceramide-1-phosphate), are potent metabolic regulators. Each of these lipids modifies in marked and specific ways the physical properties of the cell membranes, in what can be the basis for some of their physiological actions. This paper reviews the mechanisms by which these sphingolipid signals, sphingosine and ceramide in particular, are able to modify the properties of cell membranes. (c) 2006 Elsevier B.V. All rights reserved.
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