期刊
NATURE NEUROSCIENCE
卷 9, 期 12, 页码 1477-1478出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn1795
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资金
- Medical Research Council [G0100266] Funding Source: researchfish
- MRC [G0100266] Funding Source: UKRI
- Medical Research Council [G0600429, G0100266] Funding Source: Medline
NRG1, encoding neuregulin 1, is a susceptibility gene for schizophrenia, but no functional mutation causally related to the disorder has yet been identified. Here we investigate the effects of a variant in the human NRG1 promoter region in subjects at high risk of schizophrenia. We show that this variant is associated with (i) decreased activation of frontal and temporal lobe regions, (ii) increased development of psychotic symptoms and (iii) decreased premorbid IQ.
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