期刊
DEVELOPMENT
卷 133, 期 23, 页码 4631-4641出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.02655
关键词
miRNAs; microRNAs; mir-84; let-7; heterochronic pathway; molting; nuclear hormone receptors; NHR-23; NHR-25
资金
- NIGMS NIH HHS [R01 GM044619, GM44619] Funding Source: Medline
The let-7 microRNA ( miRNA) gene of Caenorhabditis elegans controls the timing of developmental events. let-7 is conserved throughout bilaterian phylogeny and has multiple paralogs. Here, we show that the paralog mir-84 acts synergistically with let-7 to promote terminal differentiation of the hypodermis and the cessation of molting in C. elegans. Loss of mir-84 exacerbates phenotypes caused by mutations in let-7, whereas increased expression of mir-84 suppresses a let-7 null allele. Adults with reduced levels of mir-84 and let-7 express genes characteristic of larval molting as they initiate a supernumerary molt. mir-84 and let-7 promote exit from the molting cycle by regulating targets in the heterochronic pathway and also nhr-23 and nhr-25, genes encoding conserved nuclear hormone receptors essential for larval molting. The synergistic action of miRNA paralogs in development may be a general feature of the diversified miRNA gene family.
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