期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 493, 期 1-2, 页码 260-270出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2015.07.062
关键词
Graphene oxide; Alginate; Cell microencapsulation; Erythropoietin; Drug delivery; Nanomedicine
资金
- National Research Program of Spain [DPI-2011-28262-C04-01]
- F.P.U. Program - Spanish Ministry for Education
- University of the Basque Country UPV/EHU [UFI 11/32]
- Basque Country Government (Grupos Consolidados)
- Ministry of Science and Innovation
Cell microencapsulation represents a great promise for long-term drug delivery, but still several challenges need to be overcome before its translation into the clinic, such as the long term cell survival inside the capsules. On this regard, graphene oxide has shown to promote proliferation of different cell types either in two or three dimensions. Therefore, we planned to combine graphene oxide with the cell microencapsulation technology. We first studied the effect of this material on the stability of the capsules and next we analyzed the biocompatibility of this chemical compound with erythropoietin secreting C2C12 myoblasts within the microcapsule matrix. We produced 160 mm-diameter alginate microcapsules with increasing concentrations of graphene oxide and did not find modifications on the physicochemical parameters of traditional alginate microcapsules. Moreover, we observed that the viability of encapsulated cells within alginate microcapsules containing specific graphene oxide concentrations was enhanced. These results provide a relevant step for the future clinical application of graphene oxide on cell microencapsulation. (C) 2015 Elsevier B.V. All rights reserved.
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