期刊
CARDIOVASCULAR DRUGS AND THERAPY
卷 20, 期 6, 页码 425-432出版社
SPRINGER
DOI: 10.1007/s10557-006-0642-0
关键词
mitochondrial permeability transition; proteomics; signaling networks; metabolism
资金
- PHS HHS [R01-80691, R01-65431, R01-63901, P01-080111, R01-71870] Funding Source: Medline
Mitochondria can serve as the arbiter of cell fate in response to stress. Mitochondrial permeability transition (NIPT) is characterized by permeabilization of an otherwise relatively impermeable mitochondrial inner membrane and appears to have a major role in ischemia/reperfusion (I/R) injury in myocardial infarction and stroke. After I/R, the fate of the cell is determined by the extent of MPT. If minimal, the cell may recover; if moderate, the cell may undergo programmed cell death; if severe, the cell may die from necrosis due to inadequate energy production. After reviewing the role of NIPT in disease, we examine the signaling and metabolic networks that regulate NIPT. We then conclude with some of the challenges in future MPT research.
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