期刊
PROTEOMICS
卷 6, 期 23, 页码 6326-6353出版社
WILEY
DOI: 10.1002/pmic.200600284
关键词
clinical proteomics; disease biomarkers; human body fluids; mass spectrometry
资金
- NIDCR NIH HHS [R01 DE015970, U01 DE016275, U01 DE016275-02, U01-DE016275, R01-DE17593, R01 DE017593-03, R01-DE15970, R01 DE017593] Funding Source: Medline
The focus of this article is to review the recent advances in proteome analysis of human body fluids, including plasma/serum, urine, cerebrospinal fluid, saliva, bronchoalveolar lavage fluid, synovial fluid, nipple aspirate fluid, tear fluid, and amniotic fluid, as well as its applications to human disease biomarker discovery. We aim to summarize the proteomics technologies currently used for global identification and quantification of body fluid proteins, and elaborate the putative biomarkers discovered for a variety of human diseases through human body fluid proteome (HBFP) analysis. Some critical concerns and perspectives in this emerging field are also discussed. With the advances made in proteomics technologies, the impact of HBFP analysis in the search for clinically relevant disease biomarkers would be realized in the future.
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