期刊
JOURNAL OF THE NEUROLOGICAL SCIENCES
卷 250, 期 1-2, 页码 27-32出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2006.06.024
关键词
motor unit number estimate (MUNE); cerebral infarction; hand weakness; hypothenar muscle group; spinal alpha motor neurons
Background: The mechanism of the decrease in motor unit number estimates (MUNEs) after cerebral infarction has not been studied systematically. We examined the relationship between the degree to which MUNEs decreased and the other clinical features of patients with the infarction. Methods: Using a multiple point stimulation technique, we obtained the MUNE of the hypothenar muscle group in 13 age-matched control subjects and 30 patients with cerebral infarction. In all patients, we obtained the Japan Stroke Scale (JSS) and head MR images. In eight patients with acute cerebral infarction, admitted within 24 h after onset, we also obtained head MR angiograms and single-photon emission CT. Findings: There was a decrease in the MUNE of the hypothenar muscle group on the affected side of 24 patients with cerebral infarction and hand weakness. The decrease in the MUNE started from 4 to 30 h after the infarction, when T1-weighted MR images of the brain involved were normal. The degree to which the MUNE decreased correlated with the part of the JSS showing the upper extremity weakness. Interpretations: A decrease in the MUNE of the hypothenar muscle group within 30 It after cerebral infarction may be due to trans-synaptic inhibition of the spinal alpha motor neurons innervating this muscle. (c) 2006 Elsevier B.V. All rights reserved.
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