期刊
JOURNAL OF ANTIBIOTICS
卷 59, 期 12, 页码 797-800出版社
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2006.105
关键词
alkysalicylic acid; Streptomyces; cytotoxic
Two new 6-alkylsalicylic acids, salaceyins A and B were isolated by bioassay-guided fractionation from the culture of the endophytic Streptomyces laceyi MS53 and their structures were determined on the basis of spectroscopic data. Salaceyins A and B exhibited modest cytotoxicity against a human breast cancer cell line (SKBR3) with IC50 values of 3.0 and 5.5 mu g/ml, respectively.
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