期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 58, 期 14, 页码 1556-1577出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2006.09.012
关键词
nanoparticles; blood-brain barrier; drug delivery; MRI; chemotherapy; photodynamic therapy; targeting
资金
- NCI NIH HHS [R24 CA083099, P01CA85878, N01-CO-37123, P50 CA093990, P50CA93990, R24CA83099] Funding Source: Medline
- NIEHS NIH HHS [R01-ES08854] Funding Source: Medline
Treatment of brain cancer remains a challenge despite recent improvements in surgery and multimodal adjuvant therapy. Drug therapies of brain cancer have been particularly inefficient, due to the blood-brain barrier and the non-specificity of the potentially toxic drugs. The nanoparticle has emerged as a potential vector for brain delivery, able to overcome the problems of current strategies. Moreover, multi-functionality can be engineered into a single nanoplatform so that it can provide tumor-specific detection, treatment, and follow-up monitoring. Such multitasking is not possible with conventional technologies. This review describes recent advances in nanoparticle-based detection and therapy of brain cancer. The advantages of nanoparticle-based delivery and the types of nanoparticle systems under investigation are described, as well as their applications. (c) 2006 Elsevier B.V. All rights reserved.
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