期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
卷 1763, 期 12, 页码 1441-1452出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamcr.2006.09.009
关键词
glyoxylate cycle; peroxisomes; membrane transport; metabolic compartmentation; Saccharomyces cerevisiae; Arabidopsis thaliana
The glyoxylate cycle provides the means to convert C-2-units to C-4-precursors for biosynthesis, allowing growth on fatty acids and C-2-compounds. The conventional view that the glyoxylate cycle is contained within peroxisomes in fungi and plants is no longer valid. Glyoxylate cycle enzymes are located both inside and outside the peroxisome. Thus, the operation of the glyoxylate cycle requires transport of several intermediates across the peroxisomal membrane. Glyoxylate cycle progression is also dependent upon mitochondrial metabolism. An understanding of the operation and regulation of the glyoxylate cycle, and its integration with cellular metabolism, will require further investigation of the participating metabolite transporters in the peroxisomal membrane. (c) 2006 Elsevier B.V. All rights reserved.
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