期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 135, 期 5, 页码 683-687出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1365-2141.2006.06348.x
关键词
myelofibrosis; MPLW515L; MPLW515K; essential thrombocythaemia
类别
MPLW515L/K and JAK2V617F can co-exist in myelofibrosis with myeloid metaplasia (MMM). The chronology of clonal emergence was studied in three such cases using serially stored bone marrow. At diagnosis, a major MPL515 mutant clone was accompanied by a minor JAK2V617F clone in all three instances. At 25 time points over a period of 4-8 years, allele burden fluctuated but remained high for MPLW515L/K and low for JAK2V617F. We conclude that MPLW515L/K and JAK2V617F are both early events in MMM and allele burden, rather than the mere presence of these mutations, might be relevant to phenotypic variation in myeloproliferative disorders.
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