期刊
THESCIENTIFICWORLDJOURNAL
卷 6, 期 -, 页码 1828-1840出版社
HINDAWI LTD
DOI: 10.1100/tsw.2006.313
关键词
dicer; microRNAs; mice; RISC; RNase III
Over 10 years ago, the lab of Victor Ambros cloned an unusual gene, lin-4, which encodes two small RNA transcripts[1]. In the past few years, hundreds more of these tiny transcripts, termed microRNAs (miRNAs), have been uncovered in over a dozen species. The functions of the first two miRNAs, lin-4 and let-7, were relatively easy to identify since they were found in forward genetic screens in Caenorhabditis elegans[1,2,3]. However, uncovering the functions of the growing list of miRNAs presents a challenge to developmental biologists. This review will describe our current understanding of how miRNAs regulate gene expression and will focus on the roles these noncoding RNAs play during the development of both invertebrate and vertebrate species.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据