期刊
NATURE REVIEWS GENETICS
卷 7, 期 12, 页码 929-939出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg1984
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资金
- Medical Research Council [G9717183] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
- MRC [G9717183] Funding Source: UKRI
- Medical Research Council [G9717183] Funding Source: researchfish
DNA signature tags (molecular barcodes) facilitate functional screens by identifying mutants in mixed populations that have a reduced or increased adaptation to a particular environment. Many innovative adaptations and refinements in the technology have been described since its original use with Salmonella; they have yielded a wealth of information on a broad range of biological processes - mainly in bacteria, but also in yeast and other fungi, viruses, parasites and, most recently, in mammalian cells. By combining whole-genome microarrays and comprehensive ordered libraries of mutants, high-throughput functional screens can now be achieved on a genomic scale.
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