期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 50, 期 12, 页码 4170-4173出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00944-06
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We investigated the enzymatic efficiency and inhibition by quinolones of Mycobacterium tuberculosis DNA gyrases carrying the previously described GyrA G88C mutation and the novel GyrA G88A mutation harbored by two multidrug-resistant clinical strains and reproduced by site-directed mutagenesis. Fluoroquinolone MICs and 50% inhibitory concentrations for both mutants were 2- to 43-fold higher than for the wild type, demonstrating that these mutations confer fluoroquinolone resistance in M. tuberculosis.
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