期刊
JOURNAL OF CLINICAL EPIDEMIOLOGY
卷 59, 期 12, 页码 1266-1273出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jclinepi.2006.01.016
关键词
comorbidity; chronic disease; risk adjustment; drug resistance; bacterial; bacterial infections
资金
- NIAID NIH HHS [K23 AI01752-01A1, R01 AI60859-01A1] Funding Source: Medline
Objectives: Comorbidities are often included in risk-factor models for nosocomial antibiotic-resistant bacterial infections, and aggregate comorbidity measures are valuable because they allow one variable to represent many. This study aimed to develop new aggregate comorbidity measures based upon the Chronic Disease Score (CDs) for assessing the comorbidity-attributable risk of methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) nosocomial infections. Study Design and Setting: For each outcome, two retrospective cohort studies of hospitalized patients were conducted. Outcomes were a first MRSA or VRE positive clinical culture obtained 48 hours or more postadmission. Each cohort was divided into development (July 1998-2001) and validation (August 2001-2003) samples. New comorbidity measures were created for MRSA (CDS-MRSA), VRE (CDS-VRE), or any nosocomial infection outcome (CDS-ID) using logistic regression and subsequently validated. Model discrimination was measured using the c-statistic. Results: Discrimination of the CDS-MRSA (c = 0.60), CDS-VRE (c = 0.65), and CDS-ID (MRSA: c = 0.57; VRE: c = 0.64) was greater than that of the original CDs (MRSA: c = 0.52; VRE: c = 0.57). Conclusion: The CDS-MRSA, CDS-VRE, and CDS-ID are new infectious disease specific comorbidity risk-adjustment measures that will be useful for the quality of future epidemiologic studies of MRSA, VRE, and other infectious diseases. (C) 2006 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据