期刊
PEPTIDES
卷 27, 期 12, 页码 3292-3298出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2006.08.008
关键词
mu opioid receptors; diet-induced obesity; arcuate nucleus
资金
- NIDDK NIH HHS [DK064584, DK32089] Funding Source: Medline
Stimulation of mu opioid receptors preferentially increases the intake of a high fat diet. In this paper we investigated whether there was a difference in the expression of mu opioid receptors between animals susceptible (Osborne-Mendel) or resistant (SSB/Pl) to obesity induced by eating a high fat diet. Immunohistochemical studies demonstrated that Osborne-Mendel rats eating a chow diet had an increased number of mu opioid receptors in the arcuate nucleus when compared to S5B/Pl rats. These immunohistochemical findings were supported by Real Time-PCR which demonstrated that the mRNA level of mu opioid receptors was also increased in the hypothalamus of osborne-Mendel rats compared to S5B/ PI rats. Low doses of the mu opioid receptor agonist DAMGO [D-Ala(2)-N-Me-Phe(4)-Glycols]enkephalin administered to Osborne-Mendel rats caused a significant increase in the preference for a diet high in fat. The same doses of DAMGO switched the diet preference of S5B/Pl rats to high fat but did not significantly increase food intake. The combination of these findings suggests that the increased levels of hypothalamic mu opioid receptors in Osborne-Mendel rats may contribute to their preference for a diet high in fat and increase their susceptibility to becoming obese. (c) 2006 Elsevier Inc. All rights reserved.
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