期刊
CLINICAL MEDICINE & RESEARCH
卷 4, 期 4, 页码 250-255出版社
MARSHFIELD CLINIC
DOI: 10.3121/cmr.4.4.250
关键词
Allelic association; Burns; CD14; IL-6; Polymorphism; Sepsis; SNP; TLR4; TNF-alpha
资金
- NIGMS [5P50GM021681-40]
Objective: To analyze allelic association with clinical outcome in a cohort of burn patients. Patients: Two hundred twenty-eight individuals with burns >= 15% total body surface area without significant non-burn related trauma who survived >48 hours post-admission were enrolled. One hundred fifty-nine of these patients were analyzed previously. Methods: Candidate polymorphisms within interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), cellular differentiation marker 14 (CD14) and toll-like receptor 4 (TLR4) were evaluated by logistic regression analysis for association with increased risk for severe sepsis (sepsis plus organ dysfunction or shock). Results: After adjustment for age, burn size, ethnicity, gender and inhalation injury, alleles at TNF-alpha (308G, p=0.013), TLR4 (+896G, p=0.027), IL-6 (174C, p=0.040) and CD14 (159C, p=0.047) were significantly associated with an increased risk for severe sepsis. Conclusions: Carriage of variant alleles at immune response genes were associated with increased risk for severe sepsis after burn injury.
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