期刊
VIRAL IMMUNOLOGY
卷 19, 期 4, 页码 602-612出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/vim.2006.19.602
关键词
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资金
- NIAID NIH HHS [AI 59590-01] Funding Source: Medline
The Filoviruses Marburg virus and Ebola virus are among the deadliest of human pathogens, causing fulminant hemorrhagic fevers typified by overmatched specific immune responses and profuse inflammatory responses. Keys to both vaccination and treatment may reside, first, in the understanding of immune dysfunctions that parallel Filoviral disease and, second, in devising ways to redirect and restore normal immune function as well as to mitigate inflammation. Here, we describe how Filoviral infections may subvert innate immune responses through perturbances of dendritic cells and neutrophils, with particular emphasis on the downstream effects on adaptive immunity and inflammation. We suggest that pivotal events may be subject to therapeutic intervention as Filoviruses encounter immune processes.
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