期刊
EXPERIMENTAL PARASITOLOGY
卷 114, 期 4, 页码 341-344出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.exppara.2006.04.004
关键词
trypanosomatidae; Trypanosoma cruzi; arginine kinase; phosphotransferases; oxidative stress; hydrogen peroxide; Chagas' disease
类别
Trypanosoma cruzi arginine kinase is a key enzyme in cell energy management and is also involved in pH and nutritional stress response mechanisms. T. cruzi epimastigotes treated with hydrogen peroxide presented a time-dependent increase in arginine kinase expression, up to 10-fold, when compared with untreated parasites. Among other oxidative stress-generating compounds tested, only nifurtimox produced more than 2-fold increase in arginine kinase expression. Moreover, parasites overexpressing arginine kinase showed significantly increased survival capability during hydrogen peroxide exposure. These findings suggest the participation of arginine kinase in oxidative stress response systems. (c) 2006 Elsevier Inc. All rights reserved.
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