期刊
CLINICAL NEUROSCIENCE RESEARCH
卷 6, 期 5, 页码 261-281出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cnr.2006.09.006
关键词
Parkinson's disease; inflammation; oxidative stress; microglia; dopaminergic neurons; diffusion tensor imaging (DTI); free radicals; dopaminergic neurodegeneration
资金
- NIMH NIH HHS [P01 MH064570] Funding Source: Medline
- NINDS NIH HHS [P01 NS031492, P01 NS043985, R21 NS049264, R01 NS034239] Funding Source: Medline
Neuroinflammatory processes play a significant role in the pathogenesis of Parkinson's disease (PD). Epidemiologic, animal, human, and therapeutic studies all support the presence of a neuroinflammatory cascade in disease. This is highlighted by the neurotoxic potential of microglia. In steady-state, microglia serve to protect the nervous system by acting as debris scavengers, killers of microbial pathogens, and regulators of innate and adaptive immune responses. In neurodegenerative diseases, activated microglia affect neuronal injury and death through production of glutamate, pro-inflammatory factors, reactive oxygen species, quinolinic acid among others and by mobilization of adaptive immune responses and cell chemotaxis leading to transendothelial migration of immunocytes across the blood-brain barrier and perpetuation of neural damage. As disease progresses, inflammatory secretions engage neighboring glial cells, including astrocytes and endothelial cells, resulting in a vicious cycle of autocrine and paracrine amplification of inflammation perpetuating tissue injury. Such pathogenic processes contribute to neurodegeneration in PD. Research from others and our own laboratories seek to harness such inflammatory processes with the singular goal of developing therapeutic interventions that positively affect the tempo and progression of human disease. (C) 2006 Association for Research in Nervous and Mental Disease. Published by Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据