期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 54, 期 12, 页码 1709-1714出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.54.1709
关键词
thalidomide; hydroxythalidomide; metabolite; tumor necrosis factor (TNF)-alpha modulator
Mono- and dihydroxylated metabolites of thalidomide were efficiently prepared and characterized, and their inhibitory activity on tumor necrosis factor (TNF)-alpha production in the human monocytic leukemia cell line THP-1 was evaluated. 5,N-Dihydroxythalidomide was a much more potent TNF-alpha production inhibitor than thalidomide.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据