期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 16, 期 23, 页码 6054-6057出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2006.08.112
关键词
proteomics; quantitative analysis; peptides; stable isotopelabeling
资金
- NCRR NIH HHS [RR17703] Funding Source: Medline
- NEI NIH HHS [EY12190, EY13877] Funding Source: Medline
D-labeled and -unlabeled N-beta-naphthyliodoacetamides have been synthesized for specific modification of the sulfhydryl groups of cysteine residues in proteins or peptides, and have been applied to quantitative analysis of several peptides. A combination of these reagents, coupled with mass spectrometry, is anticipated to serve as a useful tool for quantitative analysis of peptides and hence proteins. (c) 2006 Elsevier Ltd. All rights reserved.
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