期刊
INFECTION AND IMMUNITY
卷 74, 期 12, 页码 7014-7020出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.02063-05
关键词
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Clinical Actinobacillus actinomycetemcomitans produces cytolethal distending toxin (CDT) with titers ranging from 10(2) to 10(8) U/Mg. Single nucleotide polymorphism analysis of the cdt gene in clinical isolates identified a variation of a single amino acid at residue 281 of CdtB, which significantly affected CDT toxicity by modulating the chromatin-degrading activity of CdtB.
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