期刊
JOURNAL OF MAGNETIC RESONANCE
卷 183, 期 2, 页码 315-323出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jmr.2006.08.009
关键词
diffusion time; power-law; disordered media; fractal; scaling; walk dimension; spectral dimension; fracton
资金
- Intramural NIH HHS Funding Source: Medline
- NCRR NIH HHS [P41-RR16105] Funding Source: Medline
- NINDS NIH HHS [R01-NS36992, R01-NS42075] Funding Source: Medline
This report introduces a novel method to characterize the diffusion-time dependence of the diffusion-weighted magnetic resonance (MR) signal in biological tissues. The approach utilizes the theory of diffusion in disordered media where two parameters, the random walk dimension and the spectral dimension, describe the evolution of the average propagators obtained from q-space MR experiments. These parameters were estimated, using several schemes, on diffusion MR spectroscopy data obtained from human red blood cell ghosts and nervous tissue autopsy samples. The experiments demonstrated that water diffusion in human tissue is anomalous, where the mean-square displacements vary slower than linearly with diffusion time. These observations are consistent with a fractal microstructure for human tissues. Differences observed between healthy human nervous tissue and glioblastoma samples suggest that the proposed methodology may provide a novel, clinically useful form of diffusion MR contrast. (c) 2006 Elsevier Inc. All rights reserved.
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