期刊
NEUROBIOLOGY OF AGING
卷 27, 期 12, 页码 1870-1879出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2005.10.011
关键词
circadian; aging; light; advanced phase; melatonin rhythm; phase delay; phase shift; phase angle
资金
- NHLBI NIH HHS [R01 HL67604, R01 HL067604] Funding Source: Medline
- NIA NIH HHS [AG13854, K01 AG00810, P01 AG011412, P01 AG11412, P30 AG013854] Funding Source: Medline
The present study assessed whether advances in sleep times and circadian phase in older adults might be due to decreased responsiveness of the aging circadian clock to light. Sixteen young (29.3 +/- 5.6 years) and 14 older adults (67.1 +/- 7.4 years) were exposed to 4 h of control dim (10 lux) or bright light (3500 lux) during the night. Phase shifts of the melatonin rhythm were assessed from the nights before and after the light exposure. Bright light delayed the melatonin midpoint in both young and older adults (p < 0.001). Phase delays for the older subjects were not significantly different from those of the young subjects for either the bright or dim light conditions. The magnitude of phase delays was correlated with both sleep offset and phase angle in the older, but not the younger subjects. The present results indicate that at light intensities commonly used in research as well as clinical practice older adults are able to phase delay to the same extent as younger subjects. (c) 2005 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据