Molecularly imprinted polymers for solid phase extraction

The combination of molecularly imprinted polymers (MIPs) and solid phase extraction (SPE) is reviewed. MIPs, which have high selectivity and affinity for a predetermined molecule (template), have been used as sorbents for SPE to selectively isolate analytes from biological, pharmaceutical, and environmental samples. Solid phase extraction with molecularly imprinted polymers (MIP-SPE) is a promising technique which allows specific analytes to be selectively extracted from complex matrices. This survey summarizes the characteristics, development and application of MIP-SPE in recent years. Existed problems and the future direction of MIP-SPE are also discussed.