期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 17, 期 6, 页码 698-711出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2006.10.011
关键词
actin cytoskeleton; lens; differentiation; elongation; migration; signaling; Rho GTPases
资金
- NEI NIH HHS [P-30 EY05722, EY12201, R01 EY013573, P30 EY005722, EY013573, R01 EY012201] Funding Source: Medline
The vertebrate ocular lens is a fascinating and unique transparent tissue that grows continuously throughout life. During the process of differentiation into fiber cells, lens epithelial cells undergo dramatic morphological changes, membrane remodeling, polarization, transcriptional activation and elimination of cellular organelles including nuclei, concomitant with migration towards the lens interior. Most of these events are presumed to be influenced in large part, by dynamic reorganization of the cellular actin cytoskeleton and by intercellular and cell: extracellular matrix interactions. In light of recent and unprecedented advancement in our understanding of the mechanistic bases underlying regulation of actin cytoskeletal dynamics and the role of the actin cytoskeleton in cell function, this review attempts to summarize current knowledge regarding the role of the cellular actin cytoskeleton, in lens fiber cell elongation and differentiation, and regulation of actin cytoskeletal organization in the lens. (c) 2006 Elsevier Ltd. All rights reserved.
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