期刊
SAR AND QSAR IN ENVIRONMENTAL RESEARCH
卷 17, 期 6, 页码 583-595出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10629360601033549
关键词
DNA sequence; protein; numerical representation; graphical representation; 8 x 8 table of codons; virtual genetic code
We have introduced novel numerical and graphical representations of DNA, which offer a simple and unique characterization of DNA sequences. The numerical representation of a DNA sequence is given as a sequence of real numbers derived from a unique graphical representation of the standard genetic code. There is no loss of information on the primary structure of a DNA sequence associated with this numerical representation. The novel representations are illustrated with the coding sequences of the first exon of beta-globin gene of half a dozen species in addition to human. The method can be extended to proteins as is exemplified by humanin, a 24-aa peptide that has recently been identified as a specific inhibitor of neuronal cell death induced by familial Alzheimer's disease mutant genes.
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