期刊
CLINICAL AND EXPERIMENTAL MEDICINE
卷 6, 期 4, 页码 145-149出版社
SPRINGER
DOI: 10.1007/s10238-006-0117-4
关键词
history of medicine; metastasis; tumour growth
The outcome of cancer metastasis depends on multiple interactions between selected metastatic cells and homeostatic mechanisms unique to some organ microenvironments. The English surgeon Stephen Paget (1855-1926) is credited with being the first to postulate the important role played by microenvironment in metastasis formation. The concept of his 'seed and soil' theory has been supported and confirmed by numerous publications. This review article summarises the most important literature data about this matter.
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