期刊
NEUROBIOLOGY OF AGING
卷 27, 期 12, 页码 1769-1785出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2005.10.004
关键词
Alzheimer's disease; cerebrovascular disease; cholinesterase inhibitors; hypertension; vascular dementia
资金
- Medical Research Council [G0400074, G0500247] Funding Source: Medline
- Alzheimers Research UK [ART-PPG2005A-5] Funding Source: researchfish
- Medical Research Council [G0500247, G0400074] Funding Source: researchfish
- MRC [G0500247, G0400074] Funding Source: UKRI
Alzheimer's disease (AD) and vascular dementia (VaD) are widely accepted as the most common forms of dementia. Cerebrovascular lesions frequently coexist with AD, creating an overlap in the clinical and pathological features of VaD and AD. This review assembles evidence for a role for cholinergic mechanisms in the pathogenesis of VaD, as has been established for AD. We first consider the anatomy and vascularization of the basal forebrain cholinergic neuronal system, emphasizing its susceptibility to the effects of arterial hypertension, sustained hypoperfusion, and ischemic cerebrovascular disease. The impact of aging and consequences of disruption of the cholinergic system in cognition and in control of cerebral blood flow are further discussed. We also summarize preclinical and clinical evidence supporting cholinergic deficits and the use of cholinesterase inhibitors in patients with VaD. We postulate that vascular pathology likely plays a common role in initiating cholinergic neuronal abnormalities in VaD and AD. (c) 2005 Elsevier Inc. All rights reserved.
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