期刊
CELLULAR SIGNALLING
卷 18, 期 12, 页码 2077-2088出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2006.05.009
关键词
TGF-beta; receptor; interacting proteins; Smad; adaptor proteins; endocytosis; cross-talk
类别
资金
- NIDDK NIH HHS [R01 DK075663, R01-DK49362, R21-DK68637, KO1-DK64074-01] Funding Source: Medline
Members of the Smad protein family are fundamental downstream mediators of TGF-beta signals. However, the basic, linear Smad signaling pathway is unlikely to be the sole contributor to the plethora of cell type-specific TGF-beta responses. Investigators have identified a number of molecules that interact with the TGF-beta receptors (T beta Rs) and may explain, at least in part, the tight regulation of TGF-beta effects. Understanding these T R-interacting molecules is thus a matter of great potential significance for elucidating TGF-beta-family signal transduction. The present article reviews our current understanding of the roles and mechanisms of action of this relatively understudied group of molecules. (c) 2006 Elsevier Inc. All rights reserved.
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