期刊
TRENDS IN MICROBIOLOGY
卷 14, 期 12, 页码 536-542出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tim.2006.10.004
关键词
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资金
- NIAID NIH HHS [N01 AI 30028, U54 AI 057168, R01 AI 057927, R01 AI 036525, N01 AI 25461, U19 AI 056578, U19 AI 065683] Funding Source: Medline
One of the hallmarks of successful vaccination is the induction of strong and persistent memory T cell responses, a process that involves striking changes in the number and functional properties of T cells. Many questions pertaining to this complex, multifaceted process remain unanswered. Some of the key issues and challenges to optimize memory T cell responses and foster vaccine development include the optimization of effector T cell burst sizes, the use of adjuvants, cytokines and co-stimulatory molecules, epitope enhancement and the standardization of techniques to detect specific T cells. Age also has an impact on vaccine design because of the physiological changes in cell-mediated immunity that occur throughout life.
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