期刊
COORDINATION CHEMISTRY REVIEWS
卷 250, 期 23-24, 页码 3053-3067出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ccr.2006.04.001
关键词
supramolecular chemistry; self-assembly; molecular recognition; guanidinium cations; carboxylate receptors
Guanidinium cations are a prominent recognition motif for oxoanion binding both in Nature and in abiotic systems. However, simple ion pairing based on alkyl guanidinium cations is not strong enough to achieve an efficient complexation in aqueous solvents. Nature uses the less polar microenvironment of a protein to shield the ion pair from the solvent thereby increasing complex stability. For artificial supramolecular systems other ways to improve the binding affinity of guanidium cations have to be found. We will describe herein our use of modified acylguanidinium cations with additional H-bond donor sites to achieve oxoanion binding in aqueous solvents. The thermodynamic characterization of such systems is described as well as some applications from the field of bioorganic chemistry (e.g. artificial receptors for anionic biomolecules). (c) 2006 Elsevier B.V. All rights reserved.
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