期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 54, 期 12, 页码 1730-1733出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.54.1730
关键词
Sargassum thimbergii; tetraprenyltoluquinol; antioxidant activity; peroxynitrite
Thunbergols A (4) and B (5), tetraprenyltoluquinols, along with three known compounds (1-3) have been isolated from the brown alga Sargassum thunbergii. The structures of these two new compounds were determined to be 9-(3,4-dihydro-2,8-dimethyl-6-hydroxy-2H-1-benzopyran-2-yl)-6-methyl-2-(4-methyl-3-pentenyl)-(2E,6E)-nonadienoic acid (4) and 10-(2,3-dihydro-5-hydroxy-7-methyl-l-benzofuran-2-yl)-10-hydroxy-6-methyl-2-(4-methyl-3-pentenyl)-(2E,6E)-undecadienoic acid (5), respectively, by combined spectroscopic methods. Both of them exhibited significant scavenging activities on radical and potently inhibited generation of ONOO- from morpholinosydnonimine (SIN-1).
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