期刊
CELLULAR IMMUNOLOGY
卷 244, 期 2, 页码 130-136出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2007.01.009
关键词
germinal centers; somatic hypermutation; myasthenia gravis (MG); rheumatoid arthritis (RA); Sjogren's syndrome
资金
- Medical Research Council [G0000160] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
- MRC [G0000160] Funding Source: UKRI
- Medical Research Council [G0000160] Funding Source: researchfish
Autoimmune diseases show high diversity in the affected organs, clinical manifestations and disease dynamics. Yet they all share common features, such as the ectopic germinal centers found in many affected tissues. Lineage trees depict the diversification, via somatic hypermutation (SHM), of immunoglobulin variable-region (IGV) genes. We previously developed an algorithm for quantifying the graphical properties of IGV gene lineage trees, allowing evaluation of the dynamical interplay between SHM and antigen-driven selection in different lymphoid tissues, species, and disease situations. Here, we apply this method to ectopic GC B cell clones from patients with Myasthenia Gravis, Rheumatoid Arthritis, and Sjogren's Syndrome, using data scaling to minimize the effects of the large variability due to methodological differences between groups. Autoimmune trees were found to be significantly larger relative to normal controls. In contrast, comparison of the measurements for tree branching indicated that similar selection pressure operates on autoimmune and normal control clones. (c) 2007 Elsevier Inc. All rights reserved.
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