期刊
HUMAN IMMUNOLOGY
卷 67, 期 12, 页码 966-975出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.humimm.2006.10.008
关键词
human; tonsil; IgM memory B cells; somatic hypermutation; pneumococcal infection
类别
IgD(+)CD27(+) memory B cells are a major compartment of circulating memory B cells. However, the characteristics of these cells in the tonsils have been unclear. In this study, IgD(+)CD27(+) memory B cells residing in the tonsillar marginal zone were found to exhibit similar characteristics as IgD(+)CD27(+) memory B cells in the periphery, namely large morphology, expression of surface molecules, and hypermutated Ig variable region genes. Furthermore, these IgD(+)CD27(+) memory B cells predominantly produced IgM, including IgM specific against pneumococcal polysaccharides. Taken together, these results provide convincing evidence that tonsillar IgD(+)CD27(+) memory B cells impart protective humoral immunity against pneumococcal infection by producing high-affinity IgM. (c) American Society for Histocompatibility and Immunogenetics, 2006. Published by Elsevier Inc.
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