Cutting edge:: TLR3 stimulation suppresses experimental autoimmune encephalomyelitis by inducing endogenous IFN-β

Experimental autoimmune encepbalomyelitis is a well characterized model of cell-mediated autoimmunity. TLRs expressed on APCs recognize microbial components and induce innate immune responses, leading to the elimination of invading infectious agents. Certain TLR agonists have been reported to have adjuvant properties in CNS autoimmune inflammatory demyelination. We report in this study that TLR3 stimulation by polyinosinic polycytidylic acid, a double-stranded RATA analog, suppresses relapsing demyelination in a murine experimental autoimmune encepbalomyelitis model. Disease suppression is associated with the induction of endogenous IFN-beta and the peripheral induction of the CC chemokine CCL2. These data indicate that a preferential activation of the MyD88-independent, type I IFN-inducing TLR pathway has immunoregulatory potential in this organ-specific autoimmune disease. The Journal of Immunology, 2006, 177:7505-7509.