期刊
JOURNAL OF DENTAL RESEARCH
卷 85, 期 12, 页码 1074-1084出版社
INT AMER ASSOC DENTAL RESEARCHI A D R/A A D R
DOI: 10.1177/154405910608501202
关键词
tissue inhibitor of metalloproteinase; TIMP; matrix metalloproteinase; MMP; biological functions; oral disease; extracellular matrix
Several families of enzymes are responsible for the degradation of extracellular matrix ( ECM) proteins during the remodeling of tissues. An important family of such enzymes is that of the matrix metalloproteinases ( MMPs). To control MMP-mediated ECM breakdown, tissue inhibitors of metalloproteinases ( TIMPs) are able to inhibit MMP activity. A disturbed balance of MMPs and TIMPs is found in various pathologic conditions, such as cancer, rheumatoid arthritis, and periodontitis. The role of MMPs in pathology has been extensively described in the literature. The main focus of this review lies in the biological functions of TIMPs and their occurrence in disease, especially in the head and neck area. Their biological functions and their role in diseases like oral cancers and periodontitis, and in the development of cleft palate, will be discussed. Finally, the diagnostic and therapeutical opportunities of TIMPs will be evaluated.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据