期刊
CLINICAL IMMUNOLOGY
卷 121, 期 3, 页码 251-259出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2006.08.010
关键词
neonate; immune system; antigen-presenting cells; dendritic cells; regulatory T cells; macrophages; monocytes; childhood; costimulatory molecules; cytokines
类别
资金
- NIAID NIH HHS [R01 AI056927] Funding Source: Medline
Immaturity of the immune system has been suggested as an underlying factor for the high rate of morbidity and mortality from infections in newborns. Functional impairment of neonatal T cells is frequently quoted as the main underlying mechanism for such immaturity. However, recent studies suggest that neonatal antigen-presenting cells (APCs) also exhibit functional. alterations, which could lead to secondary defects of adaptive T-cell responses. In this review, we summarize what is known on the functionality of APC at birth and during early childhood. Compared to adults, neonatal APCs display markers of immaturity and produce low levels of cytokines. Multiple factors could be involved in neonatal APC alteration, such as intrinsic immaturity, defective interaction between APCs and T cells and regulatory T-cell-mediated inhibition. Characterization of the relative contribution of each mechanism is clearly needed to better understand the functional capability of the neonatal immune system. (c) 2006 Elsevier Inc. All rights reserved.
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