Synthesis and immunosuppressive activity of new artemisinin derivatives.: Part 2:: 2-[12(β or α)-dihydroartemisinoxymethyl-(or 1′-ethyl)]phenoxyl propionic acids and esters

Another series of novel dihydroartemisinin derivatives were synthesized and assessed for their cytotoxicity of lymphocyte, inhibitory activity on mitogen-induced spleen lymphocyte proliferation in vitro. Some of the compounds exhibited inhibitory effects on ConA-induced T cell and LPS-induced B cell proliferation comparable to or more potent than parent artemisinin. (c) 2006 Elsevier Ltd. All rights reserved.