期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 326, 期 1-2, 页码 148-152出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2006.06.037
关键词
layered double hydroxide; cordycepin; nanohybrid; intercalate
Layered double hydroxides (LDHs) were investigated as cordycepin delivery nanocarriers for the first time in this study. Negatively charged biomolecule-cordycepin was intercalated in the gallery spaces of [Mg-Al-NO3] as the charge-compensating species, which was confirmed by the results of XRD, FT-IR, TEM, CZE and electrophoretic mobility. Cell experiment suggested that the new bio-LDH nanohybrid could prevent cordycepin decomposition by adenosine deaminase. This new formulation could possibly be used as a novel form cordycepin intravenous injection. (c) 2006 Elsevier B.V. All rights reserved.
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